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Piyasa ismi Coumadin veya Warfmadin isimli ilaçların içeriğinde Warfarin bulunmaktadır. Warfarin hayati önem taşıyan bir ilaçtır.
Pıhtı önler (antikoagülan) ilaçlar, kanınızın daha uzun sürede pıhtılaşmasını sağlayarak damarlarınızın içinde zararlı kan birikintilerinin oluşmasını ve eğer varsa bunların büyümesini engeller. Ülkemizde bu amaçla kullanılan ilaç Coumadin'dir (isim değişikliği yapmış ve artık "Warfmadin" olarak piyasada bulunmaktadır.). Coumadin etken maddesi "Warfarin sodyum"dur. Coumadin dozu hastanın ilaca karşı INR değeri yanıtına göre her hasta için farklıdır. Hastanın INR değerine ve tedavi edilen duruma göre doz ayarlaması yapılmalıdır. Coumadin (Warfarin) ilacınızı nasıl ve hangi dozlarda kullanacağınıza doktorunuz karar verecektir.
Coumadin K vitaminine bağlı pıhtılaşma faktörlerinin oluşumunu engeller. K vitamini, kanın pıhtılaşmasında rol oynar. Coumadin (Warfarin) bu şekilde vücudun kan pıhtısı yapma yeteneğini azaltır. Zararlı pıhtıların oluşumunu ve var olan pıhtıların büyümesini engellemeye yardımcı olur. Coumadinin (Warfarin) etkisi tam olarak 72-96 saat içinde ortaya çıkar. İlk başlandığında istenen INR düzeyine ulaşanıncaya kadar, Coumadin’e ilave olarak, kan sulandırıcı iğneler (hazır enjektörde ve cilt altına uygulanabilen) kullanmak gerekebilir. Coumadinin etkisi ilaç kesilse bile 2 - 5 gün devam edebilir.